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In those that receive 20 h of acetylcysteine, 2 h before completion of acetylcysteine infusion check ALT/AST to determine the need for ongoing acetylcysteine
Lyons J, Rauh-Pfeiffer A, Ming-Yu Y, Lu XM, Zurakowski D, Curley M, et al
When repeated administration is expected to be relevant for the future therapeutic use of the compound, the study may subsequently progress to a Multiple Ascending Dose (MAD) phase
These findings suggest that pharmacological inhibition of FSP1 may provide an effective strategy for cancer therapy by sensitizing cancer cells to ferroptosis-inducing chemotherapeutic drugs and, if used in combination with GPX4 inhibitors, could have a strong synergistic effect
Yes, but with caution
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