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This paper reviews the most relevant experimental studies that have contributed to a better understanding of the molecular mechanisms and intracellular pathways involved in cardioprotection induced by GLP-1 and analyzes in depth its potential role as a therapeutic target both in the ischemic and reperfused myocardium and in other conditions that are associated with myocardial remodeling and heart failure

However, patients with uncontrolled or unstable DR were excluded from this trial

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These areas are critically involved in reward-related pathways, and play an important role in motivation, goal-directed behavior as well as processing of different types of reward (Berridge & Robinson, 1998