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In a pooled analysis of data from 17 clinical trials and six extension studies with empagliflozin, the incidence of events consistent with UTI was similar for placebo and empagliflozin 10 and 25 mg (11.3, 10.4, and 9.4/100 patient-years, respectively) [67]

In the last few years, that landscape has been permanently altered

The effects of selective serotonin reuptake inhibitors on male and female fertility: a brief literature review

A prescriber reconciles all of those variables, and clinical literature supplies reference ranges that inform, rather than replace, that individualized judgment

For tirzepatide, with a similar half-life, the same guidance applies