They are also looking at various mouse models of inflammation, including heart disease, atherosclerosis, and liver and kidney inflammation, to establish whether the beneficial effects of GLP-1 in each case are indeed mediated through the brain
P.BertrandR
This significantly increases the risk and severity of side effects, including severe nausea, vomiting, diarrhea, and constipation, which can lead to dehydration and kidney problems
30 At this time, the data surrounding increased risks of psychiatric conditions remain conflicting, and thus, incretin therapy initiation in this population will likely warrant some monitoring to ensure continued stability, particularly in the first month of initiation
It is the foundation of everything that follows