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The drug interaction databases classify this as a moderate interaction, noting that "as you lose weight during treatment with phentermine, your dosage requirement of tirzepatide or any other diabetic medications may change." This is not a minor technicality

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44,45 In a meta-analysis of 48 RCTs including 27,729 participants, the overall incidence of GI adverse events was reported to be 11.6%, with nausea identified as the most common symptom (21.4%)

Because of this uncertainty, Ozempic carries a boxed warning , the strongest type the FDA issues, for the potential risk of certain thyroid cancers, including medullary thyroid carcinoma

Clinicians sometimes ask, can you take phentermine and tirzepatide together, when a patient shows partial response and good tolerability