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A 6-week subcutaneous infusion of GLP-1 in patients with T2DM produced substantial improvements in insulin secretory capacity and insulin sensitivity, with a reduction in the hemoglobin A1c (HbA1c) level of 1.2% [39]
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Even as the clinical community works to establish the long-term benefits of current GLP-1 and HRT combinations, a new generation of metabolic therapies is already moving through trials, ones that extend the biological logic of this article's central argument into territory that semaglutide and tirzepatide alone cannot reach
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