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RZ, Q-CH, and PS wrote the first draft of the manuscript and interpreted the data analysis

Adjusting dose based on response Initial dosing represents a starting point, not a final destination

The results were striking: Weight Loss: At 24 weeks, retatrutide achieved mean weight reductions of 7.2% (1 mg), 12.9% (4 mg), 17.3% (8 mg), and 17.5% (12 mg), compared to 1.6% for placebo

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They work on the same pharmaceutical mechanism as GLP-1 inhibitors, so a DPP-4 could be a suitable alternative until semaglutide is available, he said