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EMBO J 43(7):11131134

In healthy people, postprandial GIP levels are approximately 4-fold higher than GLP-1 levels.55 The predicted quantity of GIPR occupied by tirzepatide is also more than that of GLP-1R (6.3-fold at 5mg, 4.6-fold at 10mg and 4.1-fold at 15mg).56 This may be the secret of the extraordinary efficacy of tirzepatide, but it is still possible that the best ratio of GLP-1 and GIP activity in a dual agonist has not been discovered

doi:10.1016/j.tem.2020.04.003

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Oxidative stress parameters and antioxidants in patients with bipolar disorder: Results from a meta-analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls