Double-blind RCT of 4% niacinamide vs
This shift reflects a more mature interpretation of the evidence: the risk is not uniform across all GLP-1 users
To answer the questions, we need to understand how GSH is generated
Patients with a personal or family history of medullary thyroid cancer, pancreatitis, or certain diabetic complications need careful risk assessment before starting GLP-1 therapy
Dietary adjustments can help firm stools and reduce bowel frequency: Eat small, light meals that are low in fat and spice Include bland foods such as rice, pasta, toast, and bananas Increase soluble fibre intake (oats, psyllium husk, cooked carrots) which absorbs water Avoid insoluble fibre (raw vegetables, wholegrain cereals) temporarily Limit fatty, fried, or spicy foods that can irritate the gut Reduce artificial sweeteners (sorbitol, mannitol) which have laxative effects Consider a temporary lactose-free diet if dairy worsens symptoms It's important to continue eating, even if you have diarrhoea, to maintain nutrition