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If youve been following weight loss medication news, youve probably seen the headlines: Wegovy now comes in a pill

The sensation of feeling cold appears to be an indirect consequence of the metabolic and body composition changes induced by the medication, rather than a direct drug effect on temperature regulation centres in the hypothalamus

Companies in this space include mitochondrial uncouplers with enhanced safety profiles (Rivus, Continuum), GDF15 targeting drugs (Novo, Lilly, Janssen), anti- activin II receptor mAb (Versanis), mir-22 inhibition (Resalis Tx) and gut-brain axis modulators (Kallyope)

Further, all GLP-1 products are required to meet the following three conditions: Comply with an applicable United States Pharmacopeia (USP) or National Formulary (NF) monograph if one exists

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