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Another key point to assess is that murine models treated in this study were affected by liver-only metastases, with the liver being a particularly GSH-rich organ, that may represent a bias for evaluating this combination as an effective response in clinical practice, considering that melanoma metastases may occur in every other organ
could be the fact that, in the latter study, proteins in the plasma samples were precipitated before disulfide bonds were reduced, which could have affected their findings [4, 13]
Epitalon was purchased from UK Peptides
No serious adverse events were reported in either dose group of the Richie et al
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