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Aging, chronic stress, poor diet, exposure to toxins, and alcohol can all lower glutathione levels

9 GSH can be depleted intracellularly either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate) via inhibition of synthesis, or by subjecting cells to oxidant stress

The enzyme HO-1, encoded by the HMOX1 gene, catalyzes the conversion of heme into carbon monoxide, biliverdin, and free iron (as we discussed in Section NRF2 -HO-1 pathway)

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however, it may not be applicable to all skin types, conditions, or sensitivities