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Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration | BMJ

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La dosis se aumenta gradualmente en incrementos de 2.5 mg cada 4 semanas segn la respuesta clnica y tolerabilidad, hasta alcanzar dosis de mantenimiento de 5-15 mg semanales

Many restaurant chains compete on volume meals, and consumers often equate volume with value