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In vitro studies have examined its interactions with keratinocytes, fibroblasts, and melanocytes, the three primary cell types of the skin

More importantly, chronic administration of these direct blockers leads to up-regulation of DAT expression [12, 13], which possibly underlie the increased risk for subsequent substance use disorders [14, 15]

[5] Nevertheless, any signs of hypersensitivity (such as a diffuse rash, wheezing, or feeling of throat tightness) warrant stopping the injection and seeking prompt medical care

10.1001/jamainternmed.2020.0009 114 WilliamJ

Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS) are available upon request to support regulatory documentation and internal laboratory compliance