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Other Effects BLOOD PRESSURE A meta-analysis of 15 trials involving 5,636 participants found that DPP-4 inhibitors compared to placebo reduced systolic BP (mean difference, -3.04 mmHg: P 6.0 mg/dL, were similar in the saxagliptin and placebo groups (272)

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The male factor has been shown to be the underlying cause of infertility in 45% of couples who have difficulty getting pregnant

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FDAs injectable-route concern highlights limited human safety data, aggregation risk, and peptide-related impurity concerns [8]