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Gwyer and colleagues (Cell Tissue Res, 2019) provide a comprehensive review of the musculoskeletal literature

A detailed look at this two-way link is in the stress and immunity article

Not effective for individuals with severe deficiencies

If you are pursuing performance or physique goals in a competitive setting, consider WADA-compliant alternatives such as Cardarine (GW-501516) for endurance or AOD-9604 for fat loss both of which should still be verified for status with your sports anti-doping authority

These include persistent tiredness and lethargy, breathlessness even with minimal exertion, heart palpitations, pale skin, and headaches