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Central nervous system involvement is further supported by GLP-1 production in caudal brainstem neurons, key integrators of vagus nerve-mediated gut-brain signaling 53,54,55,56

Nutritional support during GLP-1 treatment GLP-1 medications significantly reduce appetite, which creates both an opportunity and a challenge

doi: 10.1093/brain/awu231

AOD-9604 targets fat through the beta-3 adrenergic receptor pathway and has a quick half-life of approximately 4 minutes, hence it requires daily injections

PEGylated NPs with GLP-1 ligands and cell-penetrating arginine motifs enable an optimal balance between prolonged systemic circulation and rapid cytoplasmic uptake, improving intracellular delivery of both diagnostic and therapeutic cargos [446, 447]