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Sustained weight loss was maintained over extended treatment durations of up to 104 weeks in STEP 5 [40], while efficacy was also consistent across ethnically diverse populations, as demonstrated in STEP 6 [41] and STEP 7 [43]

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29 Hormonal Adjustments: The complex interplay of hormones regulating hunger (like ghrelin) and fullness (like leptin) can shift as the body adapts to weight loss, potentially increasing appetite or making it harder to maintain a calorie deficit

Symptoms potentially related to blood pressure changes require clinical assessment

This promotes a healthy energy balance and reduces blood sugar spikes