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The broad appeal of these drugs is showcased by the Food and Drug Administrations approval of electrophilic drugs that act by forming covalent bonds against cancer-relevant targets such as BTK 30 , EGFR 31 or KRAS G12C (ref

GIP (Glucose-Dependent Insulinotropic Polypeptide) Improves insulin sensitivity and appears to promote more favorable fat distribution (less visceral fat around organs, more subcutaneous fat under the skin)

These numbers rival or approach results seen in semaglutide and tirzepatide, and exceed many older GLP-1 medications

Nausea, vomiting, and appetite changes Mild to moderate nausea is the most common side effect

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