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In AD animal models, M1-polarized microglia frequently co-exist with iron accumulation, indicating a synergistic interaction between inflammatory activation and disrupted iron metabolism in driving neurotoxicity (Mendoza and Scharff, 2017)

Previous rodent studies demonstrated that GLP-1 receptor agonists suppressed the rewarding effects of alcohol and reduced alcohol consumption

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Furthermore, PX-12 regulates metastasis of colon cancer cells by diminishing the expression of vascular endothelial growth factor and attenuating hypoxia-inducible factor 1 subunit alpha (HIF1A) levels [227]