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It was hypothesized during this investigation that these components might be somatomedins, leading to the designation of these compounds as insulin-like growth factors. (1) Further explorations into the insulin-like growth factors involved gene-targeting approaches to potentially enhance their bioavailability and potency

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2017;97(2):721-766 3 Wilding JPH, Batterham RL, Calanna S, et al

For example, most arsenic is cleared from the blood in a few hours, but the half-life of lead in bone approaches 30 years (1)

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