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Future Directions Successful completion of Phase 1 trials enabled progression to Phase 2 studies, which would evaluate efficacy in larger patient populations

This phenomenon has been corroborated by autopsy findings in PD patients, which reveal a significant presence of activated microglia in the substantia nigra and basal ganglia regions of their brains, whereas microglia in the brain tissue of healthy individuals remain in a quiescent state (He et al., 2018)

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