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Practical Application Fatty fish: Salmon, mackerel, sardines, anchovies (2-3 servings weekly) Fish oil supplements: 1000-2000mg combined EPA+DHA daily Algae-based omega-3: 300-600mg DHA daily (vegetarian option) Flaxseed/chia: 2-3 tablespoons ground daily (ALA, less effective) Take omega-3 supplements with meals containing fat for optimal absorption Consistency matters more than timingdaily intake over weeks/months Quality matters: choose third-party tested supplements for purity Strategy 3: Protein Quality and Amino Acid Balance The Science: Specific amino acids influence DPP-4 activity through various mechanisms

doi: 10.1186/s13229-016-0088-6

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To account for the pronounced heterogeneity of the preclinical evidence base, specific inclusion criteria for preclinical studies were defined as follows: (1) Model Type: utilization of established in vivo models (e.g., transgenic AD models like APP/PS1 or 3xTg-AD, neurotoxin-induced PD models, middle cerebral artery occlusion for ischemia, or high-fat diet for metabolic dysfunction) or relevant in vitro neuronal/glial cell lines

ACS Combinatorial Science