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Freezing irreversibly damages the peptide structure, breaking the molecular bonds that allow tirzepatide to bind to GIP and GLP-1 receptors

Further, NICE and the BNF says that if there are neurological symptoms present, then every other day injections are the recommended treatment, so all the points you make about B12 being stored and sufficient are not really relevant

Some patients explore MIC injections as a complementary approach alongside GLP-1 receptor agonist medications, though no research specifically validates this combination

It is important not to freeze the solution, as this can negatively affect the peptides structure and efficacy

Beginners should start with 50mg daily for the first 1-2 weeks to assess tolerance, then progress to the standard dose of 75mg daily for weeks 3-8