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Tirzepatide, the active ingredient in Eli Lillys diabetes drug Mounjaro and weight-loss medication Zepbound, was on the US Food and Drug Administrations shortage list from December 2022 until October 2, 2024

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Dihexa acts as an analog of angiotensin IV, a compound known to stimulate brain-derived neurotrophic factor (BDNF)

Researchers with a history of pancreatitis, medullary thyroid carcinoma, or MEN2 syndrome should avoid both compounds due to the GLP-1 receptor activation component

Kemps H, Krankel N, Dorr M, et Exercise training for patients with type 2 diabetes and cardiovascular disease: what to pursue and how to do it