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As an adjunct to diet and exercise to lower blood sugar in adults with T2DM To reduce risk of hospitalization for heart failure in patients with heart disease or cardiovascular risk factors To slow progression of chronic kidney disease and reduce kidneyrelated and cardiovascular death risk in CKD patients Not approved for type 1 diabetes or treatment of diabetic ketoacidosis How does Farxiga work

Yet practical protocols use milligram doses, thousands of times higher

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Clin Gastroenterol Hepatol (2003) 1(4):26472.10.1053/S1542-3565(03)00130-7 43 Delgado-ArosSKimDYBurtonDDThomfordeGMStephensDBrinkmannBHet alEffect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans

Adverse event rates were comparable between groups, supporting a favorable safety profile