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Calocurb's data represents apples-to-apples comparison because they're measuring actual hormone levels and appetite effects in similar populations, unlike typical comparisons where ingredients like berberine might increase GLP-1 by 65% -- enough for blood glucose management or statistical significance but not appetite suppression or clinical significance

[DOI] [PubMed] [Google Scholar] Handa KKiyohara SYamakawa TIshikawa KHosonuma MSakai NKarakawa AChatani MTsuji MInagaki K, et al

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Topical Retinoids: Dermatologists may prescribe retinoid-based creams that increase cell turnover and help fade pigmentation slowly