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IF is produced by cells in the stomach and binds to B12 to form a complex, thereby allowing it to be absorbed in the intestines

This disease is the most common cause of dementia in old age

However, this risk has not been demonstrated in humans at therapeutic doses, and the warning is being reevaluated based on post-marketing surveillance data

For a broader picture of where CagriSema fits, see our GLP-1 trends in 2026 guide

In 2014, the US Food and Drug Administration (FDA) acknowledged a GRAS (Generally Recognised as Safe) notification for AOD 9604 as a food ingredient meaning the FDA raised no questions about the notifier's own safety conclusion