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Other ingredients: Calcium phosphate, Cellulose, Stearic acid (vegetable source), Silicon dioxide, Magnesium stearate (vegetable source), A food-grade coating

10 Adverse events 5% in SUSTAIN 5 8,10 AEs occurring in 5% of participants treated with Ozempic in SUSTAIN 5 Incidence of severe hypoglycemia was 1.5% across all placebo-controlled trials 1 Incidence of severe hypoglycemia or blood glucose-confirmed hypoglycemia (% of patients) was 8,10 : 8.3% with Ozempic 0.5 mg + basal insulin MET 10.7% with Ozempic 1 mg + basal insulin MET 5.3% with placebo + basal insulin MET Patients receiving Ozempic in combination with an insulin secretagogue (eg, sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia 1 ADA=American Diabetes Association

The prion protein (PrP) binds up to six Cu(II) atoms by N-terminal intrinsically disordered region (IDR) 3

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All patients reported appetite suppression and increased satiety during semaglutide treatment, which was diminished during treatment interruptions