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Immaturity of immune cells around the dural venous sinuses contributes to viral meningoencephalitis in neonates

Hepsin/ mice exhibit exacerbated APAP toxicity, resulting in more severe liver damage, elevated oxidative stress, and higher mortality

In trials, the oral 25mg dose produced strong weight loss results (see the research section above)

Waiting 4 weeks between dose escalations allows the body to adapt to increasing drug exposure and minimizes gastrointestinal adverse effects, the most common reason for treatment discontinuation

This research was supported by National Institute on Alcohol Abuse and Alcoholism grant R21AA026931