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This neural system could be abnormally developed to be activated through a low threshold in the presence of mental and/or physiologic stimuli, possibly analogous to anticipatory tachypnea patterns in patients with panic attacks.37 The prediction of this model would be that any factor that acutely alleviates stress or anxiety in patients with CVS could improve centrally driven vomiting patterns

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Metalloporphyrins, Mn cyclic polyamines, nitrogen oxides, and other compounds are included in these simulations

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