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Through extensive structure-activity studies, we have demonstrated that a physical mixture of a cyclic decapeptide, toll-like receptor 2 (TLR-2) targeting lipid peptide and GAS B cell epitope (J8) chemically-conjugated to a universal T helper cell epitope (PADRE) produced significant IgG antibodies when administered subcutaneously to mice with strong opsonisation potential against clinical GAS 9,10,11

Furthermore, by generating acylcarnitines, l-C defends the cell from acyl-CoA accretion [2]

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Furthermore, compared with the HCD group, the HCD + ALC group showed significantly decreased Srebp2 , Hmgcr , Ldlr , Apob , and Abcg8 mRNA levels and a significantly increased Abcg5 mRNA level (Figure 3H)