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Combined, these effects disrupt normal cyclic hormone patterns, change feedback to the hypothalamus and pituitary, and can result in irregular cycles, low sperm quality, or anovulation

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This suggests that SOD activity is also negatively affected in damaged spinal cord tissues during the chronic phase of SCI, which leads to a decrease in the antioxidant capacity of the spinal cord, and is an important factor in the occurrence of oxidative stress-induced injury

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