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Interestingly, Paraprevotella (AUC, 0.78), Pseudobutyrivibrio (AUC, 0.76), and Collinsella stercoris (AUC, 0.83) showed more superiority than the usual urine protein/creatinine ratio (AUC, 0.755) in discriminating CKD patients from healthy controls even at early disease stage

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Thus, it has been shown that the inhibition of PARP1 or CD38 increases NAD + levels, leading to an increase in the activity of SIRT1

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