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When taken orally, SOD supplements typically encounter several obstacles: Digestive enzymes often degrade SOD in the gastrointestinal tract The intestinal wall presents a formidable barrier to absorption Cellular membranes restrict SOD's ability to enter cells Special delivery systems or modifications are typically required to improve bioavailability This fundamental difference in bioavailability means that hydrogen water can reach cellular targets much more efficiently than exogenous SOD supplements, potentially offering more immediate protection against oxidative stress throughout the body