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The most frequently reported side effects for both include: Nausea (most common, especially during dose escalation) Diarrhea Constipation Vomiting Decreased appetite (technically the intended effect) Abdominal discomfort For tirzepatide, these side effects are well-characterized from multiple large Phase 3 trials and extensive real-world use

In more complex brightening, especially in the case of intractable hyperpigmentation or an uneven tone, this is usually noticeable in sessions 8-10

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