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Research from the STEP-1 trial extension showed that participants regained approximately two-thirds of their lost weight within one year of stopping semaglutide

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When to Adjust the Protocol Signs It's Working Progressive pain reduction week over week Gut symptoms improving (if applicable) Skin texture changes visible by weeks 4-6 Better sleep and recovery Improved range of motion Signs the Protocol Needs Adjusting No improvement by week 3: Verify peptide quality via COA, check dose (10 units at 2mL reconstitution), ensure consistent injection schedule Gut symptoms unchanged after 2 weeks: KPV should produce noticeable gut improvement by this point