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Effects of vildagliptin on ventricular function in patients with type 2 diabetes mellitus and heart failure: a randomized placebo-controlled trial

High blood pressure is a common ailment in 21st-century society caused by damage to the blood vessels and can lead to debilitating and deadly consequences from heart diseases

including 14 RCTs showed that GLP-1RAs significantly reduced weight compared to placebo (average 8.77 kg

Intracellular signal pathways are involved in numerous biological processes and have also been demonstrated to be intimately linked to the development of drug resistance

However, when ROS production becomes overwhelming, compensatory mechanisms are inadequate, and pathophysiological consequences occur