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Through co-immunoprecipitation (CO-IP) experiments, we discovered that FOXO4-DRI prevents the binding of FOXO4 to P53, facilitating the phosphorylated P53 nuclear exclusion, which subsequently trigger BAX and cleaved caspase-3, leading to the apoptosis of senescent cells

Highlights in ultrasound-targeted microbubble destruction-mediated gene/drug delivery strategy for treatment of malignancies

No physiotherapy

As a lyophilized powder, AHK-Cu is generally reported in the literature as stable under proper storage, with the copper-peptide complex conferring a degree of oxidative resistance relative to uncomplexed peptide chains

At all time points, HA-Lipo@Gel/DID exhibited a more persistent fluorescent signal and stronger retention in inflamed joints compared to free DID (Fig