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No significant differences were observed in vascular samples (aorta, femoral and radial arteries) regarding angiotensin receptors expression, with exception for lower aortic AT 1 mRNA expression in the PCZ group (Figures S5S9)

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18 However, its rapid hydrolysis by intestinal lactase and SGLT1 inhibition causing diarrhea limited its clinical use

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Diabetologia 57(4):781784 Mahase E (2024) GLP-1 agonists: US sees 700% increase over four years in number of patients without diabetes starting treatment