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Introduction The internal oxidants and antioxidants in the body are usually in balance to maintain normal life activities, while the imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage, is called oxidative stress [1]

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Reaction step metadata and metrics To facilitate the evaluation and prioritization of proposed retrosynthetic pathways, each individual reaction step suggested by our pipeline is annotated with relevant metadata

The serum testosterone concentrations were measured by electrochemiluminescence immunoassay using Elecsys Testosterone II (05200067190, Roche, Germany) according to the manufacturers instructions