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As for skin-brightening, there is a trade publication with in-vivo data showing that SAP can fade brown spots

Additionally, symptoms that could indicate pancreatitis (severe abdominal pain radiating to the back, persistent vomiting) or gallbladder disease (right upper quadrant pain, fever, jaundice) require urgent evaluation, as these are known potential complications of GLP-1 therapy

These findings suggest that growth hormone therapy during childhood and/or adolescence may lead to a better metabolic profile in adults with PWS who have del15q, but not in those with mUPD, thus lessening the phenotypic impact of the deletion

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