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Indeed, the fold change in expression of selected genes is not impressive, and thus may reduce the strength of our observations

-barr1-KO mice did not display any obvious phenotypes in a series of in vivo and in vitro metabolic tests

"We are very excited by MariTide's differentiated profile, with clinically meaningful attributes of substantial and progressive weight loss, monthly or less frequent dosing, significant improvements in cardiometabolic parameters and strong reduction of HbA1C," said Data from this Phase 2 study will be presented at a future medical congress and submitted for publication

CPNE1 achieves this by upregulating markers such as CD163, CD206, and interleukin-10 (IL-10), which are characteristic of M2 macrophages