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While the medication begins working at a molecular level within hours, most patients notice the first tangible effects within 24 to 72 hours after their shot

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Dapagliflozin's DECLARE-TIMI 58 (2019) emphasized non-inferiority for MACE (HR 0.93, 95% CI 0.841.03) while highlighting a 27% drop in HF (HR 0.73, 95% CI 0.610.88) and 17% improvement in the CV death/HF composite (HR 0.83, 95% CI 0.730.95), with enhanced outcomes in high-risk subgroups [59]

Data suggests that GLP-1R-dependent cardioprotection may also result from effects on cardiac energetic metabolism