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however, large-scale controlled human efficacy data are not yet available

Although many of the symptoms improve with treatment, some problems caused by the condition can be irreversible if left untreated, warns the NHS

Long-Term, Supplemental, One-Carbon MetabolismRelated Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort. Journal of Clinical Oncology 35 (2017): 34403448