Summary of NICE guidance for GLP-1 receptor agonists and tirzepatide in adults (PDF)
Renal Impairment: Do not initiate in patients with eGFR 30-45 mL/min
Medication and supplies included GLP-1 Liquid Drops are a sublingual form of GLP-1 therapy, absorbed under the tongue to bypass digestion and enter the bloodstream quickly
Concerns and perspectives The studies so far do not report serious side effects related to GLP-1As use, however, in high doses they can lead to gastrointestinal problems, such as nausea, vomiting and diarrhea (Hall et al., 2015
In cases where metformin is not suitable or not sufficient to achieve target blood glucose levels, healthcare providers may consider adding or switching to other medications, such as GLP-1s, DPP-4 inhibitors, SGLT-2 inhibitors, or insulin