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found that dietary Gln supplementation can elevate Gln levels in the TME, decrease the expression of immunosuppressive genes such as Ctla4 and Nrp1 in Tregs, inhibit Treg differentiation, and consequently enhance the tumor immune response (52)
Glossary References 1 Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: A systematic analysis for the global burden of disease study 2019
In other words, antioxidant administration, like pro-oxidants, may lead to a compromising cell redox imbalance controlling parasite spread
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