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They metabolize through different pathways

PMID: 39204186 Medical Disclaimer The information on this page is for educational purposes only and does not constitute medical advice, diagnosis, or treatment

MOTS-c activates AMPK (AMP-activated protein kinase), the master metabolic switch that signals cells to increase glucose uptake, accelerate fat oxidation, and promote mitochondrial biogenesis

It reduces TNF-alpha production along with IL-1beta, IL-6, IL-8, and other cytokines at the transcriptional level

Conclusion The findings suggest that exposure to Ang-II stimulating AHMs is associated with a significant reduction in dementia risk, compared to Ang-II inhibiting AHMs