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So, a major portion of a dose of phenacetin would be rapidly metabolised to paracetamol, it seemed possible that phenacetin owed some of its antipyretic activity to its main metabolite, paracetamol, whereas its most troublesome side effect (methemoglobinemia) was due to another metabolite-phenetidine

This condition is characterised by impaired glucose disposal and increased hepatic glucose production, as well as disruptions in sex hormone regulation

Aloulou et al., 2012

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