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Data are mean SEM, n = 3.(E) Biotin pull-down assay showing SIM1-Me is competitive with BRD-VHL-biotin for binding with CD36 in membrane fractions from LNCaP cells under indicated conditions.(F) Representative sensograms from surface plasmon resonance assays showing the binding affinity of SIM1-Me to an hCD36-coated Series S sensor chip CM5 from Cytiva

(1997): Changes in dopamine receptor mRNA expression following chronic mild stress and chronic antidepressant treatment

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Furthermore, the GCGR may play a role in renal energy metabolism, and GLP-1R/GCGR dual agonists such as 1907B have shown superior efficacy to GLP-1R single agonists in murine DN models, more effectively reducing proteinuria and improving renal function [232]